Hypersensitivity. Narrow-angle glaucoma, high BP, severe heart disease, history of stroke or intracranial hemorrhage, porphyria, stomach ulcer or obstruction of the gut or bladder, or kidney disease. Pregnancy & lactation.
Asthma, emphysema, chronic bronchitis or other lung diseases, high BP or other heart problems, history or active seizures, glaucoma, thyroid problems, diabetes, liver or kidney disease, enlarged prostate, bladder problems or difficulty urinating. Patients w/ toxic goiter, BPH, irregular heart rate, breathing problems & chronic cough as w/ asthma & COPD & those receiving antidepressants. May affect ability to drive or operate machinery.
Alcohol, medicines for anxiety or sleep disorder (eg, alprazolam, chlordiazepoxide, diazepam, temazepam, traizolam), medicines for depression (eg, amitriptyline, imipramine, moclobemide, sertraline), other cold/allergy medicines or any other medicines causing drowsiness, sleepiness & relaxation because of the possibility for increased sedation. Hypertensive crisis w/ MAOIs (eg, phenelzine, selegiline) & not to be used w/in 2 wk after stopping MAOIs. Possibility of increased toxicity w/ sympathomimetic agents (eg, epinephrine) & general anesth (eg, halothane). Increased CV effects w/ β-blockers (eg, carvedilol, metoprolol, propranolol).
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